![]() Miao Liu, Bo-Han Li, Tian Li, Xia Wu, Meng Liu, De-Cai Xiong, Xin-Shan Ye. ![]() Glycolipids as Antigens for Semi-Invariant Natural Killer T Cells. Seth Taylor, Shenglou Deng, Albert Bendelac, Luc Teyton, Paul B.Using agonists for iNKT cells in cancer therapy. Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action. offers 1 Sets of Blue Exorcist Shiro Fujimoto Cosplay Costume, Wig, Props and Accessories. Carlo Pifferi, Roberto Fuentes, Alberto Fernández-Tejada.New Paradigm in NKT Cell Antigens: MCS‐0208 (2‐(Hydroxymethyl)phenylthio‐phytoceramide) – an Aryl‐Phytoceramide Compound with a Single Hydroxyl Group Stimulates NKT Cells. Roser Borràs‐Tudurí, Anna Alcaide, Sandrine Aspeslag, Lorena Usero, Carmen Serra, Carme Roura‐Mir, Dirk Elewaut, Amadeu Llebaria.iNKT cell agonists as vaccine adjuvants to combat infectious diseases. Ya-Qian Li, Cheng Yan, Rui Luo, Zheng Liu.European Journal of Organic Chemistry 2022, 2022 Chemical Biology of αGalCer: A Chemist's Toolbox for the Stimulation of Invariant Natural Killer T (iNKT) Cells. ACS Infectious Diseases 2022, Article ASAP. A New iNKT-Cell Agonist-Adjuvanted SARS-CoV-2 Subunit Vaccine Elicits Robust Neutralizing Antibody Responses. Ya-Qian Li, Cheng Yan, Xi-Feng Wang, Mao-Ying Xian, Guo-Qing Zou, Xiao-Fei Gao, Rui Luo, Zheng Liu.To our knowledge, this is the first ligand that allows covalent bond formation to CD1d under physiological conditions. Furthermore, the LC-MS/MS analysis indicated that the chloroacetylamide-containing ligand was covalently bound to Cys12 of CD1d, which suggests that the enhanced activities result from the formation of a stable CD1d–ligand complex. The assay results revealed that these ligands displayed higher levels of cytokine production and Th2 cell-type cytokine polarization response. It was found that the absorption of keratin hydrolysates in solution increased during irradiation of the sample, most notably between 250210 nm. We focused on the Cys residue of the large hydrophobic pockets of CD1d (A′ pocket) and developed α-GalCer derivatives containing groups that can form covalent bonds. Synopsis An investigation into the influence of UV irradiation on keratin hydrolysates was carried out using UVVis spectroscopy, Fourier transform infrared spectroscopy (FTIR) and fluorescence spectroscopy. Previous structure–activity relationship studies of α-GalCer have revealed that the ability of NKT cells to induce cytokines depends on the ligand structure, and in particular, ligands that form more stable complexes with CD1d display potent activity. The resulting complex is recognized by the T cell receptors of the NKT cell, inducing various immune responses. α-Galactosyl ceramide (α-GalCer, KRN7000) is the representative CD1d ligand that can bind to the CD1d protein. ![]() CD1d is a nonpolymorphic antigen-presenting protein responsible for the regulation of natural killer T (NKT) cell activation. ![]()
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